umbilical cord blood expert's

A team of U.S. researchers has shown that therapy with cells from umbilical cord blood, has an important role in reducing lesions after a stroke (CVA), which remains the main cause of death in Portugal. The study is published in the Journal of Neuroscience Research.

Several studies have confirmed the efficacy of cell therapy with cord blood human umbilical, reducing ischemic injury in rats, and these effects been partly attributed to the reduction of neuroinflammation. However, the mechanisms involved in reducing neuroinflammation, offered by cell therapy stem were not yet understood.

The research, conducted now shows that stem cell therapy suppressed the recruitment of pro-inflammatory cells to the site of ischemia, thus presenting a potential mechanism for the protective effects of therapy cell after the induction of an ischemic rat.

In this work, we studied two groups of animals, a cell treated stem cord blood and others with a control without cells, 48 hours after the ischemic attack. The systemic injection of cells from blood cord reduced the magnitude of the immune response, and the total area occupied cells, which trigger the inflammatory response was

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The extracellular matrix (complex network of proteins and polysaccharides secreted by cells) stem cells mesenchymal cells of umbilical cord blood can inhibit the growth of tumor cells in metastatic tumors aggressive, a study published in the journal Cancer Letters .

The study authors show that this result is achieved because the extracellular matrix of mesenchymal stem cells obtained from umbilical cord blood cells induce tumor increased levels of a protein with anti- tumor. Simultaneously, this matrix induces the secretion of a Another factor that suppresses a signaling pathway quite important in tumor formation.

In this investigation, tumor cells of breast cancer were two days exposed during the mesenchymal stem cells from Cord blood and was then injected into female mice. After 43 days, the volumes of tumors in group treated with stem cells were significantly lower than in control animals.

The study shows that the extracellular matrix stem cells umbilical cord blood could inhibit the growth of cancer cells and has the potential to suppress the progression tumor.

Cancer is a complex disease in which there is a relationship dynamics between tumor cells and the microenvironment that involves. In tumors are cancer stem cells that have some characteristics in common with stem cells normal. Both types of stem cells are deeply
influenced by their microenvironments surrounding the that dictates their cell fate and behavior.

Understanding the inhibitory effect of cell microenvironment mesenchymal stem cells may ultimately allow the development of new therapeutic strategies to combat cancer.

David Ferreira, Crioestaminal responsible physician, states that ”This is a work of research that clarifies the relationship between some substances from the extracellular matrix produced by mesenchymal stem cells, with inhibitory potential of tumor growth and may thus help in defining new therapeutic targets in treatment of cancer. “

The umbilical cord is a structure that connects the fetus to the placenta.

It’s sort of means of communication between baby and mother, consisting of 3 channels (blood vessels) – two arteries and one vein – wrapped in a kind of jelly (the jelly of Wharton).

This jelly not only keeps the channels together and protects them and prevents them from collapsing. The vein is wider, thinner wall and therefore more fragile. The arteries are narrower and have thicker walls. The vessels entering the fetus at the umbilicus and placenta, usually at its center.
The arteries carry blood, already with little oxygen, and products to be

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Multiplication of stem cells from umbilical cord blood increase efficiency of transplants in leukemia

A study recently published in the journal Nature Medicine shows that stem cells from umbilical cord blood can be expanded in the laboratory, significantly increasing the speed of recovery hematopoiesis (production of blood cells by the bone marrow) and efficiency of transplantation.

In this scientific study describes the development of a methodology optimal and clinically feasible, allowing the cells to expand progenitor stem cells from umbilical cord blood in order to clinical use. The ex vivo culture of these cells in the presence of

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